{"id":3145,"date":"2026-04-16T15:26:20","date_gmt":"2026-04-16T15:26:20","guid":{"rendered":"https:\/\/hfhpulm.com\/info\/?page_id=3145"},"modified":"2026-06-08T18:23:14","modified_gmt":"2026-06-08T18:23:14","slug":"endura-2","status":"publish","type":"page","link":"https:\/\/hfhpulm.com\/info\/?page_id=3145","title":{"rendered":"ENDURA-2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Inclusion<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Age between 40 and 80 years old.<\/li>\n\n\n\n<li>BMI of 16 kg\/m<sup>2<\/sup> or above.<\/li>\n\n\n\n<li>Historical Blood Eosinophil Count of \u2265150 cells\/mcL.\u00a0 The patient must have a Count of \u2265300 cells\/mcL at time of Screening Visit 0 or 1.\u00a0 Make sure they don\u2019t have conditions that artificially elevate Eosinophils.\u00a0<\/li>\n\n\n\n<li>COPD Diagnosis for at least 1 year.<\/li>\n\n\n\n<li>Post-BD FEV1\/FVC ratio of &lt; 70%.<\/li>\n\n\n\n<li>Post-BD FEV1 > 30% and \u2264 80%.<\/li>\n\n\n\n<li>Either on Triple Therapy or at least LAMA\/LABA.<\/li>\n\n\n\n<li>At least 2 moderate COPD exacerbations (requiring ICS) or 1 severe COPD exacerbation (requiring hospitalization) in the past 12 months.<\/li>\n\n\n\n<li>Current or Former Smoker of 10 or more pack-years.<\/li>\n\n\n\n<li>Patient can be on up to 15 mg of oral steroid (e.g., prednisone) each day, but they must have been on them for at least 6 months and had a stable dose for the last 3 months.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Exclusion<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Must not have asthma diagnosis.<\/li>\n\n\n\n<li>No other clinically significant lung diseases besides COPD (e.g., sarcoidosis of the lung, Pulmonary HTN, lung fibrosis, lung cancer, ILD, etc.)<\/li>\n\n\n\n<li>No pneumonia, COPD exacerbation, or LRTIs within 4 weeks of screening.<\/li>\n\n\n\n<li>No lung resection ever.<\/li>\n\n\n\n<li>Cannot be within acute phase of pulmonary rehab within 4 weeks.<\/li>\n\n\n\n<li>Cannot be using continuous oxygen therapy for more than 12 hours\/day.<\/li>\n\n\n\n<li>No use of CPAP or BiPAP machines.<\/li>\n\n\n\n<li>No other unstable and clinically significant diseases of other organ systems.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/hfhpulm.com\/info\/wp-content\/uploads\/2026\/04\/ENDURA-2-protocol.pdf\">Full protocol<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inclusion Exclusion Full protocol<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3145","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/pages\/3145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3145"}],"version-history":[{"count":2,"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/pages\/3145\/revisions"}],"predecessor-version":[{"id":3161,"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=\/wp\/v2\/pages\/3145\/revisions\/3161"}],"wp:attachment":[{"href":"https:\/\/hfhpulm.com\/info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}