Inclusion
- Age between 40 and 80 years old.
- BMI of 16 kg/m2 or above.
- Historical Blood Eosinophil Count of ≥150 cells/mcL. The patient must have a Count of ≥300 cells/mcL at time of Screening Visit 0 or 1. Make sure they don’t have conditions that artificially elevate Eosinophils.
- COPD Diagnosis for at least 1 year.
- Post-BD FEV1/FVC ratio of < 70%.
- Post-BD FEV1 > 30% and ≤ 80%.
- Either on Triple Therapy or at least LAMA/LABA.
- At least 2 moderate COPD exacerbations (requiring ICS) or 1 severe COPD exacerbation (requiring hospitalization) in the past 12 months.
- Current or Former Smoker of 10 or more pack-years.
- Patient can be on up to 15 mg of oral steroid (e.g., prednisone) each day, but they must have been on them for at least 6 months and had a stable dose for the last 3 months.
Exclusion
- Must not have asthma diagnosis.
- No other clinically significant lung diseases besides COPD (e.g., sarcoidosis of the lung, Pulmonary HTN, lung fibrosis, lung cancer, ILD, etc.)
- No pneumonia, COPD exacerbation, or LRTIs within 4 weeks of screening.
- No lung resection ever.
- Cannot be within acute phase of pulmonary rehab within 4 weeks.
- Cannot be using continuous oxygen therapy for more than 12 hours/day.
- No use of CPAP or BiPAP machines.
- No other unstable and clinically significant diseases of other organ systems.