Your 54-year-old male patient who is a lifelong nonsmoker comes back to your office for followup of a RUL nodule after a recent biopsy you performed revealed stage IV non-small cell lung cancer. His oncologist said that a “signet ring” sign was seen on his biopsy and that he has a gene abnormality seen on the FISH sample. The patient wants to know your opinion of how well people with his condition respond to traditional chemotherapy and if there are any new drugs on the horizon which could help.