You are seeing in clinic a new patient who is a 55 yo woman from Japan. She moved to the US 30 years ago to attend graduate school. She has a 35 pack year smoking history and underwent lung cancer screening CT scan. On CT a 4cm LLL mass was seen, with bulky mediastinal lymphadenopathy. You send her for bronchoscopy and transbronchial biopsy and pathology reveals adenocarcinoma.
You send the pathology slides for immunohistochemical staining. Which of the following genotypes is she most likely to have? Why?
A) KRAS mutation
B) EGFR mutation
C) ALK gene rearrangement mutation
B. EGFR mutation
– Becuase whe is my peeps (asian). this mutation is common in asian origin and is actually a good prognostic indicator as EGFR TK inhibitors (erlotinib) maybe used in treatment.
*Because
*she